Dapoxetine, marketed as, priligy and, westoxetin, among and other brands, is the dapoxetine first compound developed specially for the treatment of premature ejaculation (PE) in dapoxetine with tadalafil dapoxetine and sildenafil brands in india men 1864 years old. 2 3, dapoxetine works by inhibiting the serotonin transporter, increasing serotonin's action at the post synaptic cleft, and as dapoxetine a dapoxetine tablet consequence promoting ejaculatory delay. 4, as a member of the selective serotonin reuptake inhibitor (ssri) family, dapoxetine was initially created as an antidepressant. However, unlike other ssris, dapoxetine is absorbed and eliminated rapidly in the body. Its fast acting property makes it suitable for the treatment of PE but not as an antidepressant. Eli Lilly pharmaceutical company, dapoxetine was sold. Johnson Johnson in 2003 and submitted. New Drug Application to the, food and Drug Administration (FDA) for the treatment of PE in 2004. 6, dapoxetine is sold in several European and Asian countries, and in Mexico. In the US, dapoxetine has been in phase III development since 2003. However, it is expected to be marketed soon. 4, in 2012, Menarini acquired the rights to commercialise Dapoxetine in Europe, most of Asia, Africa, Latin America and the Middle East. 7, contents, therapeutic uses edit. Premature ejaculation edit, randomized, double blind, placebo-controlled trials have confirmed the efficacy of dapoxetine for the treatment. 8, different dosage has different impacts on different types. Dapoxetine 60 mg significantly improves the mean intravaginal ejaculation latency time (ielt) compared to that of dapoxetine 30 mg in men with lifelong PE, but there is no difference in men with acquired. 9, dapoxetine, given 13 hours before sexual episode, prolongs ielt and increases the sense of control and sexual satisfaction in men of 18 to 64 years of age with. Since PE is associated with personal distress and interrelationship difficulty, dapoxetine provides help for men with PE to overcome this condition. 10, with no drug approved specifically for treatment for PE in the US and some other countries, other ssris such as fluoxetine, paroxetine, sertraline, fluvoxamine, and citalopram have been used off-label to treat. Waldinger's meta-analysis shows that the use of these conventional antidepressants increases ielt two- to nine-fold dapoxetine above baseline, compared to three- to eight-fold when dapoxetine is used. 9 However, these ssris may need to be taken daily in order to achieve meaningful efficacy, and their comparatively longer half-lives increase the risk of drug accumulation and a corresponding increase of adverse effects such as reduced libido. 11 Dapoxetine, on the other hand, is generally categorized as a fast-acting ssri. It is more rapidly absorbed and mostly eliminated from dapoxetine the body within a few hours. These pharmacokinetics are more favorable in that they might minimize drug accumulation in the body, habituation, dapoxetine and side effects. Contraindications edit A contraindication is a situation in which a drug should not be used, because it may be harmful to the patient. 12 Dapoxetine should not be used in men with moderate to severe hepatic impairment and in those receiving CYP3A4 inhibitors such as ketoconazole, ritonavir, dapoxetine and telithromycin. Dapoxetine can also not be used in patients with heart failure, permanent pacemaker, or other significant ischemic heart disease. Caution is advised in men receiving thioridazine, monoamine oxidase inhibitors, ssris, serotonin-norepinephrine reuptake inhibitors, or tricyclic antidepressant. If a patient stops taking one of these drugs, he should wait for 14 days before taking dapoxetine. If a patient stops taking dapoxetine, he should wait for 7 days before receiving these drugs. 4 Adverse effects edit The most common effects when taking dapoxetine are nausea, dizziness, dry mouth, headache, diarrhea, and insomnia. 13 14 Discontinuation due to adverse effects is dose related. According to McMahon in recent study in Asia, the rate of discontinuation.3,.7, and.3 of 1067 studied subjects with placebo, dapoxetine 30 mg, and dapoxetine 60 mg respectively. 15 Unlike other ssris used to treat depression, which have been associated with high incidences of sexual dysfunction, 16 dapoxetine is associated with low rates of sexual dysfunction. Taken as needed, dapoxetine has very mild adverse effects of decreased libido ( 1) and ED ( 4). Overdose edit No case of drug overdose has been reported during clinical trials.
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